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Pharmacogenetic Testing

Personalized Medicine.

Unique to your DNA.

Advanced Genetic Solutions offers a comprehensive suite of genetic tests, allowing providers to personalize treatment plans.

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What is Pharmacogenetic Testing?

A DNA test for medication

You inherit thousands of genes from your parents. Some genes determine characteristics such as your eye color, whereas other genes are responsible for how your body processes medications.

Pharmacogenomic testing is the analysis of how a person’s genes affect their response to different medications. This new field allows health care providers to combine genomics and pharmacology to develop safe and effective medication dosages that are specific to an individual's DNA.

This medical DNA testing practically eliminates the possibility of adverse drug reactions, eliminating the trial-and-error approach to selecting an effective medication and decreasing the risk of life-threatening side effects.

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What Pharmacogenetic Testing Does

The purpose of pharmacogenomic testing is to find out if a medication is right for you.

A small blood or saliva sample can help determine:

  • Whether a medication may be an effective treatment for you
  • What the best dose of a medication is for you
  • Whether you could have serious side effects from a medication

The laboratory looks for changes or variants in one or more genes that can affect your response to certain medications.

Pharmacogenomic testing helps empower your doctor with the exact information needed to prescribe you the best medication for your unique body.

The Facts

82

82%

Adults take at least one medication

29

29%

Adults take five or more medications

85

85%

Patients have detectible variants in their DNA that increase their risk for an adverse drug reaction

100,000

Deaths per year are due to adverse drug effects

8.6 Million

Adverse drug reactions are reported in the United States

2.2 Million

Adverse drug reactions reported in the United States are severe

How Does Pharmacogenetic (PGx) Testing Work?

Biologic enzymes found in our liver act upon certain target substrates and then trigger a metabolic chain reaction. This data can then be used to help physicians avoid drugs that would be inefficiently metabolized and guide them towards drugs that use more robust metabolic pathways.

By isolating and examining the regions of a patient’s DNA that code for the enzymes of interest, we can provide answer to the following questions:

How well does the patient metabolize drugs and what personal factors are being used to aid in drug selection?

PGx acts as a lifelong prescribing roadmap, steering the provider towards drugs that are metabolized efficiently and away from those that are not.

How do enzymes interact with their targets and how does the patient's genetic makeup affect these interactions?

Enzymes modify drugs into their active and inactive metabolites. A person’s genetic makeup may seriously affect how well certain enzymes perform.

Is there a system to identify when a patient is taking a medication that is poorly suited for them?

PGx acts as a safeguard, protecting both physician and patient from undesirable adverse drug reactions.

How can a physician mitigate drug-drug interactions when a patient is prescribed multiple medications?

PGx flags potentially dangerous interactions between drugs and often suggests suitable alternatives.

Why Should Patients Get Tested?

Patients have differences in DNA that impact drug metabolism that may increase their likelihood of an adverse drug reaction:

  • More than 85% of the population have detectable variations in their DNA that increase their risk for adverse drug reactions.

  • Adverse drug reactions are the 4th leading cause of death nationwide with more than 8.6 million cases reported annually.

  • The FDA highlights pharmacogenomics data for more than 130 prescription medications, indicating their strong support for testing.

Who To Test?

Advanced Genetic Solutions advises pharmacogenomics testing for patients that meet one or more of the following conditions:

  • Patients that experience less than optimal results from prescribed medications.

  • Patients with a personal or family history of adverse drug reactions in response to certain medications.

  • Polypharmacy patients; those taking multiple prescription medications for multiple chronic conditions.

Benefits of Testing?

Understanding a patient’s genetic background allows a physician to predict how a prescribed drug will relate with that patient, giving the clinician insight into not only clinical efficacy, but also potential undesired drug reactions. Additional benefits include:

  • More than 85% of the population have detectable variations in their DNA that increase their risk for adverse drug reactions.

  • Adverse drug reactions are the 4th leading cause of death nationwide with more than 8.6 million cases reported annually.

  • The FDA highlights pharmacogenomics data for more than 130 prescription medications, indicating their strong support for testing.

Pharmacogenomic testing is a powerful tool that can help your health care provider determine the best medication for you.

With this simple saliva-based test, you and your physician may get a better idea of how you might respond to certain drugs.

Find out information about how your DNA might affect your response to certain medications.

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